Consanguineous Iranian kindreds with severe Tourette syndrome
Identifieur interne : 002343 ( Main/Exploration ); précédent : 002342; suivant : 002344Consanguineous Iranian kindreds with severe Tourette syndrome
Auteurs : Maria G. Motlagh [États-Unis, Iran] ; Arshia Seddigh [Iran, Royaume-Uni] ; Behnoosh Dashti [Iran] ; James F. Leckman [États-Unis] ; Javad Alaghband-Rad [Iran, Canada]Source :
- Movement Disorders [ 0885-3185 ] ; 2008-10-30.
English descriptors
- KwdEn :
Abstract
The search for vulnerability genes for Tourette syndrome has been ongoing for nearly three decades. The contribution of recessive loci with reduced penetrance is one possibility that has been difficult to explore. Homozygosity mapping has been successfully used to detect recessive loci within populations with high rates of consanguinity. Using this technique, even quite small inbred families can be informative due to autozygosity in which the two alleles at an autosomal locus are identical by descent (i.e., copies of a single ancestral gene). To explore the utility of this approach, we identified 12 consanguineous Iranian families. Remarkably, these families were seen with an unusual natural history characterized by the early onset of vocal tics and coprolalia and frequent comorbidity with obsessive‐compulsive disorder. Genotyping the affected and unaffected members of these pedigrees has the potential to identify rare recessive contributions to this disorder. © 2008 Movement Disorder Society
Url:
DOI: 10.1002/mds.22261
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 002778
- to stream Istex, to step Curation: 002778
- to stream Istex, to step Checkpoint: 000948
- to stream Main, to step Merge: 002538
- to stream Main, to step Curation: 002343
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Consanguineous Iranian kindreds with severe Tourette syndrome</title>
<author><name sortKey="Motlagh, Maria G" sort="Motlagh, Maria G" uniqKey="Motlagh M" first="Maria G." last="Motlagh">Maria G. Motlagh</name>
</author>
<author><name sortKey="Seddigh, Arshia" sort="Seddigh, Arshia" uniqKey="Seddigh A" first="Arshia" last="Seddigh">Arshia Seddigh</name>
</author>
<author><name sortKey="Dashti, Behnoosh" sort="Dashti, Behnoosh" uniqKey="Dashti B" first="Behnoosh" last="Dashti">Behnoosh Dashti</name>
</author>
<author><name sortKey="Leckman, James F" sort="Leckman, James F" uniqKey="Leckman J" first="James F." last="Leckman">James F. Leckman</name>
</author>
<author><name sortKey="Alaghband Ad, Javad" sort="Alaghband Ad, Javad" uniqKey="Alaghband Ad J" first="Javad" last="Alaghband-Rad">Javad Alaghband-Rad</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:DF83BA3CEE79E2BA46C8577C6A4DE6D20537745D</idno>
<date when="2008" year="2008">2008</date>
<idno type="doi">10.1002/mds.22261</idno>
<idno type="url">https://api-v5.istex.fr/document/DF83BA3CEE79E2BA46C8577C6A4DE6D20537745D/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">002778</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002778</idno>
<idno type="wicri:Area/Istex/Curation">002778</idno>
<idno type="wicri:Area/Istex/Checkpoint">000948</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000948</idno>
<idno type="wicri:doubleKey">0885-3185:2008:Motlagh M:consanguineous:iranian:kindreds</idno>
<idno type="wicri:Area/Main/Merge">002538</idno>
<idno type="wicri:Area/Main/Curation">002343</idno>
<idno type="wicri:Area/Main/Exploration">002343</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Consanguineous Iranian kindreds with severe Tourette syndrome</title>
<author><name sortKey="Motlagh, Maria G" sort="Motlagh, Maria G" uniqKey="Motlagh M" first="Maria G." last="Motlagh">Maria G. Motlagh</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Child Study Center Yale University School of Medicine, New Haven, Connecticut</wicri:regionArea>
<placeName><region type="state">Connecticut</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Iran</country>
<wicri:regionArea>Department of Psychiatry, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran</wicri:regionArea>
<wicri:noRegion>Tehran</wicri:noRegion>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Connecticut</region>
</placeName>
<wicri:cityArea>Child Study Center, Yale University School of Medicine, I‐265 SHM, 230 South Frontage Road, New Haven</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Seddigh, Arshia" sort="Seddigh, Arshia" uniqKey="Seddigh A" first="Arshia" last="Seddigh">Arshia Seddigh</name>
<affiliation wicri:level="1"><country xml:lang="fr">Iran</country>
<wicri:regionArea>Department of Psychiatry, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran</wicri:regionArea>
<wicri:noRegion>Tehran</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Psychological Medicine, Institute of Psychiatry at the Maudsley, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dashti, Behnoosh" sort="Dashti, Behnoosh" uniqKey="Dashti B" first="Behnoosh" last="Dashti">Behnoosh Dashti</name>
<affiliation wicri:level="1"><country xml:lang="fr">Iran</country>
<wicri:regionArea>Department of Psychiatry, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran</wicri:regionArea>
<wicri:noRegion>Tehran</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Leckman, James F" sort="Leckman, James F" uniqKey="Leckman J" first="James F." last="Leckman">James F. Leckman</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Child Study Center Yale University School of Medicine, New Haven, Connecticut</wicri:regionArea>
<placeName><region type="state">Connecticut</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Alaghband Ad, Javad" sort="Alaghband Ad, Javad" uniqKey="Alaghband Ad J" first="Javad" last="Alaghband-Rad">Javad Alaghband-Rad</name>
<affiliation wicri:level="1"><country xml:lang="fr">Iran</country>
<wicri:regionArea>Department of Psychiatry, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran</wicri:regionArea>
<wicri:noRegion>Tehran</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia</wicri:regionArea>
<wicri:noRegion>Nova Scotia</wicri:noRegion>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="sub">Official Journal of the Movement Disorder Society</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2008-10-30">2008-10-30</date>
<biblScope unit="volume">23</biblScope>
<biblScope unit="issue">14</biblScope>
<biblScope unit="page" from="2079">2079</biblScope>
<biblScope unit="page" to="2083">2083</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">DF83BA3CEE79E2BA46C8577C6A4DE6D20537745D</idno>
<idno type="DOI">10.1002/mds.22261</idno>
<idno type="ArticleID">MDS22261</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Tourette syndrome</term>
<term>coprolalia</term>
<term>homozygosity mapping</term>
<term>recessive inheritance</term>
<term>self‐injurious behavior</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The search for vulnerability genes for Tourette syndrome has been ongoing for nearly three decades. The contribution of recessive loci with reduced penetrance is one possibility that has been difficult to explore. Homozygosity mapping has been successfully used to detect recessive loci within populations with high rates of consanguinity. Using this technique, even quite small inbred families can be informative due to autozygosity in which the two alleles at an autosomal locus are identical by descent (i.e., copies of a single ancestral gene). To explore the utility of this approach, we identified 12 consanguineous Iranian families. Remarkably, these families were seen with an unusual natural history characterized by the early onset of vocal tics and coprolalia and frequent comorbidity with obsessive‐compulsive disorder. Genotyping the affected and unaffected members of these pedigrees has the potential to identify rare recessive contributions to this disorder. © 2008 Movement Disorder Society</div>
</front>
</TEI>
<affiliations><list><country><li>Canada</li>
<li>Iran</li>
<li>Royaume-Uni</li>
<li>États-Unis</li>
</country>
<region><li>Angleterre</li>
<li>Connecticut</li>
<li>Grand Londres</li>
</region>
<settlement><li>Londres</li>
</settlement>
</list>
<tree><country name="États-Unis"><region name="Connecticut"><name sortKey="Motlagh, Maria G" sort="Motlagh, Maria G" uniqKey="Motlagh M" first="Maria G." last="Motlagh">Maria G. Motlagh</name>
</region>
<name sortKey="Leckman, James F" sort="Leckman, James F" uniqKey="Leckman J" first="James F." last="Leckman">James F. Leckman</name>
<name sortKey="Motlagh, Maria G" sort="Motlagh, Maria G" uniqKey="Motlagh M" first="Maria G." last="Motlagh">Maria G. Motlagh</name>
</country>
<country name="Iran"><noRegion><name sortKey="Motlagh, Maria G" sort="Motlagh, Maria G" uniqKey="Motlagh M" first="Maria G." last="Motlagh">Maria G. Motlagh</name>
</noRegion>
<name sortKey="Alaghband Ad, Javad" sort="Alaghband Ad, Javad" uniqKey="Alaghband Ad J" first="Javad" last="Alaghband-Rad">Javad Alaghband-Rad</name>
<name sortKey="Dashti, Behnoosh" sort="Dashti, Behnoosh" uniqKey="Dashti B" first="Behnoosh" last="Dashti">Behnoosh Dashti</name>
<name sortKey="Seddigh, Arshia" sort="Seddigh, Arshia" uniqKey="Seddigh A" first="Arshia" last="Seddigh">Arshia Seddigh</name>
</country>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Seddigh, Arshia" sort="Seddigh, Arshia" uniqKey="Seddigh A" first="Arshia" last="Seddigh">Arshia Seddigh</name>
</region>
</country>
<country name="Canada"><noRegion><name sortKey="Alaghband Ad, Javad" sort="Alaghband Ad, Javad" uniqKey="Alaghband Ad J" first="Javad" last="Alaghband-Rad">Javad Alaghband-Rad</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002343 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002343 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Canada |area= ParkinsonCanadaV1 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:DF83BA3CEE79E2BA46C8577C6A4DE6D20537745D |texte= Consanguineous Iranian kindreds with severe Tourette syndrome }}
This area was generated with Dilib version V0.6.29. |